This book introduces cutting-edge methods on security in spectrum management, mobile networks and next-generation wireless networks in the era of artificial intelligence (AI) and machine learning (ML). This book includes four parts: (a) Architecture Innovations and Security in 5G Networks, (b) Security in Artificial Intelligence-enabled Intrusion Detection Systems. © Attack and Defense in Artificial Intelligence-enabled Wireless Systems, (d) Security in Network-enabled Applications. The first part discusses the architectural innovations and security challenges of 5G networks, highlighting novel network structures and strategies to counter vulnerabilities. The second part provides a comprehensive analysis of intrusion detection systems and the pivotal role of AI and machine learning in defense and vulnerability assessment. The third part focuses on wireless systems, where deep learning is explored to enhance wireless communication security. The final part broadens the scope, examining the applications of these emerging technologies in network-enabled fields.