Nasira Nassif is a vampire business magnate, living in New York City with her temperamental werewolf girlfriend, Annie Goldstein. All is not well in the city's supernatural world: someone is kidnapping paranormal women, dressing them in fine clothes, and leaving them on the side of the road with a very important part missing-- their hearts. The police don't care much, and neither does Nasira-- until Annie is the one missing.
Joined by Annie's veteran older brother, Nasira scours the city for her beloved, while Annie tries to keep the weird smiling guy from stabbing her to death in his basement.